Analysis of cytokine gene polymorphisms in patients with chronic diffusional liver diseases in Perm krai

Aim. To estimate the concentration of tumor necrosis factor-alpha (TNF-α), interleukin-6 (interleukin, IL-6), vascular endothelial growth factor (VEGF) in blood serum and to analyze polymorphism TNF-α cytokine genes region 308G / A (rs1800629), IL-6 174G C (rs1800795) VEGFA 634G (rs2010963) patients with chronic diffuse liver diseases (CDLD) living Perm region. Materials methods. In 193 CDLD 90 healthy donors, cytokines was studied by ELISA analysis gene PCR performed. Results. CDLD, pro-inflammatory TNF-α, level VEGF were significantly higher than control (p <0.001, respectively), while maximum inflammation markers noted cirrhosis, production - hepatitis C. Comparative single nucleotide polymorphisms showed significant differences occurrence GA AA genotypes (G-308A), carriage CG variant (C-174G), as well allele CC homozygote for marker (G-634C), which population recorded more often cohort allows us consider them genetic risk developing CDLD. Conclusion. An increase pathogenetically can develop against background these molecules. Genetic be used assess progression